Refer to the following important safety details for information on intended use, potential side effects and risks, considerations for specific groups, and possible drug interactions linked to the prescription treatments mentioned.
Reporting Side Effects
Riovie encourages users to promptly report any side effects or adverse reactions to a licensed healthcare provider and the pharmacy that dispensed the medication. To report suspected reactions to these medications, contact the FDA at 1-800-FDA-1088 or visit www.fda.gov/medwatch.
For emergencies, call 911 or go to your nearest emergency department.
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Riovie’s Role
Riovie connects users with licensed healthcare providers for evaluations regarding the suitability of the treatments advertised. It may also assist with prescription coordination through an external pharmacy network.
Riovie acts as a managed services provider and does not offer medical advice, fill prescriptions, or function as a licensed healthcare facility or pharmacy. Instead, it provides technology and administrative support to enable medical consultations and prescription logistics. For further details, see Riovie’s Terms of Service.
Promotional Offers on riovie.com
Occasionally, the website may present promotional pricing or special introductory offers. Pricing may change at any time due to supply or market conditions at the discretion of riovie.com. Introductory or promotional pricing, including “first month” offers, applies only to the plan and product listed at the time of purchase.
Prescriptions and Medications
Prescription drugs require evaluation and approval by a qualified healthcare provider, and issuance is solely at the provider’s discretion. Access to treatment plans and medications is not assured.
Prescriptions issued through Riovie may be filled by licensed pharmacies within its affiliated network.
All prescription medications involve potential risks. Please review all associated safety details and consult your provider for personalized advice.
Compounded Drug Formulations
In certain situations, healthcare providers may prescribe compounded medications, which are custom-prepared by licensed compounding pharmacies based in the U.S. These medications are not FDA-approved for safety or effectiveness but may be used when alternatives are not available or appropriate.
Riovie helps facilitate compounded medication fulfillment via its partner pharmacy network. These formulations are personalized to meet individual patient requirements and may differ from commercial products.
Trademark Notice
Riovie is not affiliated with, sponsored by, or endorsed by the manufacturer of any brand-name medication. Any brand names referenced are the property of their respective owners and are used for identification only.
Contact Information
For any questions about Riovie’s services or advertising content, please reach out to support@riovie.com.
NAD+ — Subcutaneous Injection
Important Safety Information Regarding Compounded NAD+
Please be aware that compounded drugs are not FDA-approved and do not undergo clinical studies to evaluate for safety and efficacy. Your healthcare provider may prescribe compounded NAD+ based on your medical consultation.
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell that participates in normal cellular energy metabolism and repair processes. It is prescribed at a provider’s discretion as part of a broader wellness plan. It is not a treatment for any disease, and it is not a treatment for addiction, cognitive decline, or any neurological condition.
Do not use NAD+ if:
- You have had an allergic reaction to NAD+, nicotinamide, or to any component of the formulation.
- You are pregnant, trying to become pregnant, or breastfeeding.
- You have an active or suspected malignancy.
Inform your healthcare provider if you:
- Have liver or kidney disease.
- Have low blood pressure, or a heart or circulatory condition.
- Have diabetes or impaired glucose tolerance.
- Have a history of gout or elevated uric acid.
- Take niacin, another form of vitamin B3, or any other prescription medication or supplement.
Serious risks include:
- Serious allergic reactions
- Chest tightness or difficulty breathing during or shortly after a dose
- Drops in blood pressure, with light-headedness or fainting
- Injection-site infection if aseptic technique is not followed
Common side effects: flushing, warmth, chest tightness, nausea, stomach cramping, headache, light-headedness, fatigue, and pain, redness or swelling at the injection site. These are most often related to how quickly a dose is delivered rather than the dose itself.
Administration: Inject subcutaneously on the schedule and at the dose your clinician sets. Use aseptic technique, inject slowly, and rotate sites between doses. Do not increase your dose or inject faster to save time — that is what brings on flushing and chest tightness. Do not change your dose or frequency without speaking to your clinician.
Monitoring: Watch for reactions especially when you start and whenever your dose changes. Your provider may order laboratory work before or during treatment.
Reporting side effects: Contact the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
NAD+ — Nasal Spray
Important Safety Information Regarding Compounded NAD+ Nasal Spray
Compounded NAD+ nasal spray is not FDA-approved but may be prescribed legally based on your provider’s assessment. The spray delivers the same compounded active ingredient as the injection by a different route; the amount absorbed can differ between routes and between individuals.
All of the contraindications, precautions and serious risks listed for NAD+ injection above apply equally to the nasal spray. Review that section in full before starting.
Inform your healthcare provider if you also:
- Have nasal polyps, chronic sinusitis, frequent nosebleeds, or any condition affecting the lining of your nose.
- Have recently had nasal or sinus surgery, or an injury to your nose.
- Use any other nasal spray, including over-the-counter decongestants or steroid sprays.
Common side effects: flushing, warmth, nausea, headache, light-headedness, and fatigue, plus route-specific effects — nasal irritation, burning, dryness, congestion, sneezing, runny nose, nosebleed, or a temporary change in taste or smell. Nasal delivery avoids injection-site reactions entirely, but nasal and sinus irritation is more likely. Seek care right away for wheezing, chest tightness, or trouble breathing.
Administration: Prime the bottle before first use as directed. Spray into the nostril at the dose and frequency your clinician sets, breathing in gently rather than sniffing hard. Do not share the bottle with anyone else, and replace it as instructed.
Monitoring: Watch for reactions especially when you start and whenever your dose changes. Your provider may order laboratory work before or during treatment.
Reporting side effects: Contact the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
